Zopiclone (Imovane) is indicated for the short-term remedy and symptomatic aid of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.

Treatment with zopiclone should often not exceed 7-10 consecutive days. Use for more than 2-3 consecutive weeks requires complete re-evaluation of the affected person. Prescriptions for zopiclone must be written for short-term use (7-10 days) and it shouldn’t be prescribed in quantities exceeding a 1-month provide.

The use of hypnotics must be restricted for insomnia where disturbed sleep leads to impaired daytime functioning.

Dosage and administration:

Imovane should only be taken when you are able to get a full night time’s sleep (7 to eight hours) earlier than you have to be active again.
The standard grownup dose of zopiclone is one pill simply before you go to bed.
This treatment must be taken in a single consumption and never readministered during the same evening.
If you’re over 65 years of age the dose is half a tablet taken simply before you go to mattress.
If you might have a liver or kidney problem, the similar old recommended dose is half a tablet taken simply before you go to mattress.

Overdosage:

Signs and symptoms:

Overdose by zopiclone tablets is often manifested by various levels of central nervous system despair ranging from drowsiness to coma according to the amount ingested. In delicate cases, signs embrace drowsiness, confusion, and lethargy; in more severe cases, symptoms may embrace ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory melancholy, and coma. Overdose should not be life threatening unless combined with different CNS depressants, including alcohol. Other threat components, such as the presence of concomitant sickness and the debilitated state of the affected person, might contribute to the severity of signs and really hardly ever may end up in deadly outcome.

In voluntary or unintentional circumstances of zopiclone overdosage involving doses up to 340 mg, the principal results reported had been prolonged sleep, drowsiness, lethargy and ataxia.

Recommended therapy:

Symptomatic and supportive remedy in adequate clinical environment is beneficial, consideration ought to be paid to respiratory and cardiovascular functions. Gastric lavage or activated charcoal is simply helpful when performed quickly after ingestion.

Hemodialysis is of no worth due to the massive quantity of distribution of zopiclone. Flumazenil may be a helpful antidote; nevertheless, flumazenil administration could contribute to the appearance of neurological signs (agitation, anxiousness, convulsionsand emotional lability). Intravenous fluids must be administered as wanted.